Clec4e^tm1Tks
Targeted Allele Detail

Summary

• Symbol: Clec4e^tm1Tks
• Name: C-type lectin domain family 4, member e; targeted mutation 1, Takashi Saito
• MGI ID: MGI:5013826
• Synonyms: Mincle^-
• Gene: Clec4e Location: Chr6:123258748-123266829 bp, - strand Genetic Position: Chr6, 58.35 cM, cytoband F3
• Alliance: Clec4e^tm1Tks page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172959
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The coding region of exon 1 and 2 were replaced with a neo cassette. The absence of protein expression was confirmed by western blot analysis on unstimulated and Malassezia-stimulated thioglycolate-elicited peritoneal macrophages. (J:172959)

Generation of the Clec4e^tm1Tks allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Clec4e Mutation: 24 strains or lines available

References

• Original: J:172959 Yamasaki S, et al., C-type lectin Mincle is an activating receptor for pathogenic fungus, Malassezia. Proc Natl Acad Sci U S A. 2009 Feb 10;106(6):1897-902
• All: 21 reference(s)