Tg(MMTV-ERBB2*,-luc)6157Aami
Transgene Detail

Summary

• Symbol: Tg(MMTV-ERBB2*,-luc)6157Aami
• Name: transgene insertion 6157, Augusto Amici
• MGI ID: MGI:5013830
• Synonyms: delta16HER2-LUC, Tg(delta16HER2-LUC)6157Acam
• Transgene: Tg(MMTV-ERBB2*,-luc)6157Aami Location: unknown
• Alliance: Tg(MMTV-ERBB2*,-luc)6157Aami page

Tg(MMTV-ERBB2*,-luc)6157Aami/0 mice develop spontaneous mammary tumors

Show the 2 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Humanized sequence, Inserted expressed sequence, Reporter)
• Mutation: Insertion
• Tg(MMTV-ERBB2*,-luc)6157Aami expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  ERBB2 (2064)

  Erbb2

  (MGI:95410)

• Mutation details: The MMTV promoter drives mammary gland-specific expression of human ERBB2 with an in-frame deletion of exon 16 (variant identified in human breast carcinomas) and an IRES-luciferase. Lines 6157, 6177, and 6180 were generated. (J:172352)

Schematic representation of Tg(MMTV-ERBB2*,-luc)6157Aami

Disease models

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:172352 Marchini C, et al., The Human Splice Variant Delta16HER2 Induces Rapid Tumor Onset in a Reporter Transgenic Mouse. PLoS One. 2011;6(4):e18727
• All: 9 reference(s)