Tg(Klk8-tTA)SMmay
Transgene Detail

Summary

• Symbol: Tg(Klk8-tTA)SMmay
• Name: transgene insertion S, Mark Mayford
• MGI ID: MGI:5014077
• Synonyms: Neuropsin-htTa, Nop-tTA, Prss19-tTA1, Prss19-tTA line 1, TgEC-tTA, tTA-EC
• Transgene: Tg(Klk8-tTA)SMmay Location: unknown
• Alliance: Tg(Klk8-tTA)SMmay page

Transgene origin

• Strain of Origin: (C57BL/6 x DBA)F2
• Project Collection: Neuroscience Blueprint cre

Transgene description

• Transgene Type: Transgenic (Transactivator)
• Mutation: Insertion
• Mutation details: An ~120 kb mouse bacterial artificial chromosome (BAC) containing the entire mouse kallikrein related-peptidase 8 (Klk8; also called Prss19 or neuropsin) locus, and ~50 kb of upstream and ~70 kb of downstream sequences, was modified by targeting a human codon-optimized tetracycline-regulated transactivator gene (tTA or htTA or "Tet-Off") into the first exon upstream of the Prss19 translation initiation site. The resulting modified BAC was microinjected into (C57BL/6;DBA)F2 embryos. Founder mice were bred to C57BL/6J inbred mice to establish founder line S. (J:108340, J:151755)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:151755 NIH Neuroscience Blueprint Cre Driver Network, Cre recombinase-expressing mice generated for the NIH Neuroscience Blueprint Cre Driver Network. MGI Direct Data Submission. 2009
• All: 18 reference(s)