Lrp5^tm3.2Mawa
Targeted Allele Detail

Summary

• Symbol: Lrp5^tm3.2Mawa
• Name: low density lipoprotein receptor-related protein 5; targeted mutation 3.2, Matthew Warman
• MGI ID: MGI:5014217
• Gene: Lrp5 Location: Chr19:3634828-3736564 bp, - strand Genetic Position: Chr19, 3.33 cM, cytoband B
• Alliance: Lrp5^tm3.2Mawa page

Analysis of bone mass in Lrp5^tm3.2Mawa/Lrp5^tm3.2Mawa, Hivep3^tm1Glm/Hivep3^tm1Glm, and double mutant mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:172746
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and a loxP site and FRT flanked inverted neo cassette were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed exon 2. (J:172746)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrp5 Mutation: 82 strains or lines available

References

• Original: J:172746 Cui Y, et al., Lrp5 functions in bone to regulate bone mass. Nat Med. 2011 Jun;17(6):684-91
• All: 2 reference(s)