Mir21a^tm1Yoli
Targeted Allele Detail

Summary

• Symbol: Mir21a^tm1Yoli
• Name: microRNA 21a; targeted mutation 1, Yong Li
• MGI ID: MGI:5014257
• Gene: Mir21a Location: Chr11:86474893-86474984 bp, - strand Genetic Position: Chr11, 51.82 cM
• Alliance: Mir21a^tm1Yoli page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173464
• Parent Cell Line: iTL BA1 (ES Cell)
• Strain of Origin: (C57BL/6NTac x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: The entire sequence (located in the 3' UTR of Vmp1) was replaced with a neo cassette via homologous recombination. No change in the level of expression of Vmp1 is detected compared to wild-type controls. (J:173464)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Mir21a Mutation: 8 strains or lines available

References

• Original: J:173464 Ma X, et al., Loss of the miR-21 allele elevates the expression of its target genes and reduces tumorigenesis. Proc Natl Acad Sci U S A. 2011 Jun 21;108(25):10144-9
• All: 27 reference(s)