Tg(Upk2-cre)1Rkl
Transgene Detail

Summary

• Symbol: Tg(Upk2-cre)1Rkl
• Name: transgene insertion 1, Raghu Kalluri
• MGI ID: MGI:5014304
• Synonyms: UPK II-Cre
• Transgene: Tg(Upk2-cre)1Rkl Location: unknown
• Alliance: Tg(Upk2-cre)1Rkl page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Upk2-cre)1Rkl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Upk2 (MGI:98913)

• Mutation details: The mouse promoter drives urinary bladder-specific expression of cre with a polyadenylation sequence. A 3.4 kb fragment of the murine Upk2 promoter was cloned in front of cre recombinase and a polyadenylation signal. The construct was used for pronuclear injection of C57BL/6 oocytes. Founder information is not available. The pound symbol (#) is used when no line is specified and/or lines are pooled. (J:173505, J:197843)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Upk2 (mouse) Summary of all recombinase alleles driven by Upk2. Comparative matrix view of recombinase activities Alliance mouse Upk2 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:173505 Ayala de la Pena F, et al., Loss of p53 and Acquisition of Angiogenic MicroRNA Profile Are Insufficient to Facilitate Progression of Bladder Urothelial Carcinoma in Situ to Invasive Carcinoma. J Biol Chem. 2011 Jun 10;286(23):20778-87
• All: 9 reference(s)