Bscl2^tm1.2Gliu
Targeted Allele Detail

Summary

• Symbol: Bscl2^tm1.2Gliu
• Name: BSCL2 lipid droplet biogenesis associated, seipin; targeted mutation 1.2, George Liu
• MGI ID: MGI:5014325
• Synonyms: seipin^-
• Gene: Bscl2 Location: Chr19:8814831-8826047 bp, + strand Genetic Position: Chr19, 5.76 cM
• Alliance: Bscl2^tm1.2Gliu page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173404
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3. An FRT-flanked neomycin resistance cassette with a 3' loxP site was inserted downstream of exon 3. Flp- and cre-mediated recombination removed the neo cassette and exon 3, respectively. The absence of transcript expression was confirmed by qRT-PCR on white adipose tissue, brown adipose tissue, bone marrow, liver, kidney, and skeletal muscle extracts. (J:173404)

Disease models

Expression

In Structures Affected by this Mutation:

11 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Bscl2 Mutation: 36 strains or lines available

References

• Original: J:173404 Cui X, et al., Seipin ablation in mice results in severe generalized lipodystrophy. Hum Mol Genet. 2011 Aug 1;20(15):3022-30
• All: 17 reference(s)