Trp53^tm1.2Awbr
Targeted Allele Detail

Summary

• Symbol: Trp53^tm1.2Awbr
• Name: transformation related protein 53; targeted mutation 1.2, AW Braithwaite
• MGI ID: MGI:5014809
• Synonyms: delta122p53
• Gene: Trp53 Location: Chr11:69471185-69482699 bp, + strand Genetic Position: Chr11, 42.83 cM, cytoband B2-C
• Alliance: Trp53^tm1.2Awbr page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173271
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination of Trp53^tm1.1Awbr removed exons 3 and 4, which encode the first 122 amino acids (transactivation and proline rich domains). The predicted protein corresponds to human isoform delta133p53 generated from an alternative transript initiation site in intron 4. (J:173271)

Disease models

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Trp53^tm1.2Awbr

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trp53 Mutation: 240 strains or lines available

References

• Original: J:173271 Slatter TL, et al., Hyperproliferation, cancer, and inflammation in mice expressing a Delta133p53-like isoform. Blood. 2011 May 12;117(19):5166-77
• All: 5 reference(s)