Mir146^tm2.1Bal
Targeted Allele Detail

Summary

• Symbol: Mir146^tm2.1Bal
• Name: microRNA 146; targeted mutation 2.1, David Baltimore
• MGI ID: MGI:5049868
• Gene: Mir146 Location: Chr11:43265224-43265288 bp, - strand Genetic Position: Chr11, 25.68 cM
• Alliance: Mir146^tm2.1Bal page

Enlarged spleen and lymph nodes and multiorgan inflammation in Mir146^tm1.1Bal/Mir146^tm1.1Bal and Mir146^tm2.1Bal/Mir146^tm2.1Bal mice

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173671
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The 295 bp of the pre-microRNA was replaced with a floxed neo cassette. Cre-mediated recombination removed the neo cassette. The absence of transcript expression was confirmed by qRT-PCR on bone marrow, spleen, and thymus extracts. (J:173671)

Generation of Mir146^tm1.1Bal and Mir146^tm2.1Bal alleles

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	6 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Mir146^tm2.1Bal

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir146 Mutation: 9 strains or lines available

References

• Original: J:173671 Boldin MP, et al., miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice. J Exp Med. 2011 Jun 6;208(6):1189-201
• All: 7 reference(s)