Tg(CMV-Tsc2*)1Arbi
Transgene Detail

Summary

• Symbol: Tg(CMV-Tsc2*)1Arbi
• Name: transgene insertion 1, Jack Arbiser
• MGI ID: MGI:5049894
• Synonyms: deltaRG
• Transgene: Tg(CMV-Tsc2*)1Arbi Location: unknown
• Alliance: Tg(CMV-Tsc2*)1Arbi page

Transgene origin

• Strain of Origin: C57BL/6

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(CMV-Tsc2*)1Arbi expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Tsc2 (MGI:102548)

• Mutation details: The delta-RG (DRG) transgenic construct contains a mutant mouse Tsc2 (tuberous sclerosis 2) cDNA, lacking the sequence encoding the rabaptin-5 and rap1GAP motifs, under control of the CMV (cytomegalovirus) promoter. Line 1 was generated. (J:96943)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:96943 Govindarajan B, et al., Transgenic expression of dominant negative tuberin through a strong constitutive promoter results in a tissue-specific tuberous sclerosis phenotype in the skin and brain. J Biol Chem. 2005 Feb 18;280(7):5870-4
• All: 6 reference(s)