Tg(Slc6a3-icre/ERT2)2Gloss
Transgene Detail

Summary

• Symbol: Tg(Slc6a3-icre/ERT2)2Gloss
• Name: transgene insertion 2, Bernd Gloss
• MGI ID: MGI:5049906
• Synonyms: DAT-iCreER
• Transgene: Tg(Slc6a3-icre/ERT2)2Gloss Location: unknown
• Alliance: Tg(Slc6a3-icre/ERT2)2Gloss page

Transgene origin

• Strain of Origin: C57BL/6NTac

Transgene description

• Transgene Type: Transgenic (Inducible, Recombinase)
• Inducer: tamoxifen
• Mutation: Insertion
• Tg(Slc6a3-icre/ERT2)2Gloss expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Slc6a3 (MGI:94862)

• Mutation details: The mouse bacterial artificial chromosome (BAC) RP23-408F13 containing Slc6a3, solute carrier family 6 (neurotransmitter transporter, dopamine), member 3, gene, was modified by insertion of sequence encoding iCreER at the Slc6a3 translation initiation ATG, and addition of a Kozak sequence upstream of the ATG. This BAC also contains the following genes: Clptm1l (CLPTM1-like), Tert (telomerase reverse transcriptase), and Slc6a18 (solute carrier family 6 (neurotransmitter transporter), member 18). The modified BAC was used to generate the DAT-iCreER transgene, which was microinjected into C57BL/6NTac fertilized eggs. Founder line 2 was subsequently established. (J:173676)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Slc6a3 (mouse) Summary of all recombinase alleles driven by Slc6a3. Alliance mouse Slc6a3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:173676 Gloss B, Generation of an inducible Slc6a3 cre transgene. MGI Direct Data Submission. 2011
• All: 7 reference(s)