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Rr14tm1.1Bulg
Targeted Allele Detail
Summary
Symbol: Rr14tm1.1Bulg
Name: regulatory region 14; targeted mutation 1.1, Michael Bulger
MGI ID: MGI:5049943
Synonyms: HS-E1 deletion
Gene: Rr14  Location: unknown  Genetic Position: Chr7, Syntenic
Alliance: Rr14tm1.1Bulg page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173283
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Modified regulatory region, Null/knockout)
Mutation:    Intergenic deletion
 
Mutation detailsHomologous recombination replaced a segment of genomic DNA located between Hbb-bh0 and Hbb-bh1 with a loxP site flanked neomycin resistance gene cassette. The segment of DNA replaced extended from 7500 bp downstream of the epsilon y-globin transcription start site to 8231 bp downstream (731 bp). The selectable marker was subsequently removed by crossing to Tg(CMV-cre)1Cgn transgenic mice. (J:173283)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr14 Mutation:  0 strains or lines available
References
Original:  J:173283 Fromm G, et al., An embryonic stage-specific enhancer within the murine beta-globin locus mediates domain-wide histone hyperacetylation. Blood. 2011 May 12;117(19):5207-14
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory