Mcoln1^tm1Asoy
Targeted Allele Detail

Summary

• Symbol: Mcoln1^tm1Asoy
• Name: mucolipin 1; targeted mutation 1, Abigail Soyombo-Shoola
• MGI ID: MGI:5050099
• Synonyms: Trpml1^-
• Gene: Mcoln1 Location: Chr8:3550458-3565232 bp, + strand Genetic Position: Chr8, 1.92 cM
• Alliance: Mcoln1^tm1Asoy page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173516
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A tetracycline responsive transcriptional activator was place downstream of the promoter followed by a neomycin selection cassette. This insertion replaced exons 1 and 2 and part of exon 3. Northern blot analysis of brain RNA confirmed the absence of mRNA. (J:173516)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Mcoln1 Mutation: 41 strains or lines available

References

• Original: J:173516 Chandra M, et al., A role for the Ca2+ channel TRPML1 in gastric acid secretion, based on analysis of knockout mice. Gastroenterology. 2011 Mar;140(3):857-67
• All: 3 reference(s)