Btaf1^m1Fme
Chemically induced Allele Detail

Summary

• Symbol: Btaf1^m1Fme
• Name: B-TFIID TATA-box binding protein associated factor 1; mutation 1, Frits Meijlink
• MGI ID: MGI:5050316
• Synonyms: Btaf1^V1330M
• Gene: Btaf1 Location: Chr19:36903479-36990152 bp, + strand Genetic Position: Chr19, 32.02 cM
• Alliance: Btaf1^m1Fme page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: Mice were identified in a screen of ENU mutants for developmental defects. Mice have a G to A transition in exon 28 at position 4299 of cDNA ENSMUST00000099494 leading to a valine to methionine substitution at amino acid residue 1330 in the ATPase domain. Western blot analysis indicates that protein levels are 10% of levels in controls. (J:173663)

Expression

In Mice Carrying this Mutation:	8 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Btaf1 Mutation: 109 strains or lines available

References

• Original: J:173663 Wansleeben C, et al., An ENU-induced point mutation in the mouse Btaf1 gene causes post-gastrulation embryonic lethality and protein instability. Mech Dev. 2011 May-Jun;128(5-6):279-88
• All: 1 reference(s)