Tg(tetO-Fasl)BDepa
Transgene Detail
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Symbol: |
Tg(tetO-Fasl)BDepa |
Name: |
transgene insertion B, Monique De Paepe |
MGI ID: |
MGI:5050406 |
Synonyms: |
(tetOp)7-FasL transgenic line B, TetOp-FasL transgenic line B |
Transgene: |
Tg(tetO-Fasl)BDepa Location: unknown
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Alliance: |
Tg(tetO-Fasl)BDepa page
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Transgene Type: |
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Transgenic (Inducible, Inserted expressed sequence) |
Inducer: |
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doxycycline/tetracycline |
Mutation: |
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Insertion
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Tg(tetO-Fasl)BDepa expresses
1 gene
Transgene expresses:
Organism |
Expressed Gene |
Note |
mouse |
Fasl (MGI:99255) |
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Mutation details: The (tetO)7-FasL transgene was designed with a Tet response element (TRE) upstream of the 943 bp murine Fas ligand (FasL) coding sequence, all followed by a bovine growth hormone intron and polyA sequence. The Tet response element (TRE) contains seven copies of the 42-bp tet operator sequence (tetO) just upstream of a minimal CMV promoter. Five founder lines (A-E) were established. Founder mice from line B were found with ~6 copies of the transgene and high levels of doxycycline-induced FasL mRNA up-regulation.
(J:137382)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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Original: |
J:169681 De Paepe ME, et al., Alveolar epithelial cell therapy with human cord blood-derived hematopoietic progenitor cells. Am J Pathol. 2011 Mar;178(3):1329-39 |
All: |
3 reference(s) |
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