Mitf^tm3.1Arnh
Targeted Allele Detail

Summary

• Symbol: Mitf^tm3.1Arnh
• Name: melanogenesis associated transcription factor; targeted mutation 3.1, Heinz Arnheiter
• MGI ID: MGI:5050699
• Synonyms: Mitf^mi-deltaD
• Gene: Mitf Location: Chr6:97784013-97998310 bp, + strand Genetic Position: Chr6, 45.05 cM
• Alliance: Mitf^tm3.1Arnh page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:188155
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: (C57BL/6N x 129S6/SvEvTac)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The targeted mutation deleted the D promoter, exon 2D and the flanking intron by the addition of a floxed neomycin selection cassette. The selection cassette was subsequently removed by cre excision. (J:188155)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mitf Mutation: 74 strains or lines available

Notes

Targeted recombination occurred in LC3 ES cells.

References

• Original: J:188155 Bharti K, et al., A regulatory loop involving PAX6, MITF, and WNT signaling controls retinal pigment epithelium development. PLoS Genet. 2012 Jul;8(7):e1002757
• All: 2 reference(s)