Inpp5d^el20
Chemically induced Allele Detail

Summary

• Symbol: Inpp5d^el20
• Name: inositol polyphosphate-5-phosphatase D; early lethal
• MGI ID: MGI:5050823
• Synonyms: Ship1^el20
• Gene: Inpp5d Location: Chr1:87548034-87648229 bp, + strand Genetic Position: Chr1, 44.44 cM, cytoband C5
• Alliance: Inpp5d^el20 page

Mutation origin

• Strain of Origin: 129

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: A T to C transition was found at nucleotide position 2099 (Genbank NM_010566) in ENU mutant mice. This should cause an isoleucine to threonine change at amino acid residue 641. An in-vitro 5'-phosphatase assay demonstrated reduced enzyme activity as compared to un-mutated controls. Protein levels were reduced in Western blots as were mRNA levels by qRT-PCR. (J:173266)

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Inpp5d Mutation: 94 strains or lines available

References

• Original: J:173266 Nguyen NY, et al., An ENU-induced mouse mutant of SHIP1 reveals a critical role of the stem cell isoform for suppression of macrophage activation. Blood. 2011 May 19;117(20):5362-71
• All: 1 reference(s)