Ptgds^{tm1.1(cre)Gvn}
Targeted Allele Detail

Summary

• Symbol: Ptgds^{tm1.1(cre)Gvn}
• Name: prostaglandin D2 synthase (brain); targeted mutation 1.1, Marco Giovannini
• MGI ID: MGI:5051626
• Synonyms: PGDSCre
• Gene: Ptgds Location: Chr2:25356721-25360058 bp, - strand Genetic Position: Chr2, 17.28 cM
• Alliance: Ptgds^{tm1.1(cre)Gvn} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173718
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Ptgds^{tm1.1(cre)Gvn} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Ptgds (MGI:99261)

• Mutation details: A targeting vector was constructed with the nls-cre recombinase sequence fused to exon 1 of the Ptgds locus and a poly A signal with a floxed EGFP-hygromycin selection cassette 3' to the cre poly A signal. Homologous recombination in ES cells was performed to replace exon 1 with the targeting construct. Chimeras were crossed with FVB/N mice. The floxed selection cassette was excised by crossing offspring to the Tg(EIIa-cre)C5379Lmgd deletor line and the EIIa transgene was bred from the background. (J:173718)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Ptgds (mouse) Summary of all recombinase alleles driven by Ptgds. Alliance mouse Ptgds gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ptgds Mutation: 17 strains or lines available

References

• Original: J:173718 Kalamarides M, et al., Identification of a progenitor cell of origin capable of generating diverse meningioma histological subtypes. Oncogene. 2011 May 19;30(20):2333-44
• All: 3 reference(s)