Rnase10^tm1(cre)Hht
Targeted Allele Detail

Summary

• Symbol: Rnase10^tm1(cre)Hht
• Name: ribonuclease, RNase A family, 10 (non-active); targeted mutation 1, Ilpo Huhtaniemi
• MGI ID: MGI:5051834
• Synonyms: Tg(Rnase10Cre)
• Gene: Rnase10 Location: Chr14:51245208-51248215 bp, + strand Genetic Position: Chr14, 26.34 cM, cytoband C1
• Alliance: Rnase10^tm1(cre)Hht page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173897
• Parent Cell Line: AB2.2 (ES Cell)
• Strain of Origin: 129S7/SvEvBrd-Hprt1^b-m2

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Rnase10^tm1(cre)Hht expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Rnase10 (MGI:1922269)

• Mutation details: An iCre and FRT flanked PGK-neomyucin resistance cassette was inserted in exon 2 replacing the first 8 nucleotides which includes the initiation site. Cre expression was confirmed by RT-PCR analysis of RNA samples from segments I and II of the proximal epididymis. (J:173897)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Rnase10 (mouse) Summary of all recombinase alleles driven by Rnase10. Alliance mouse Rnase10 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rnase10 Mutation: 13 strains or lines available

References

• Original: J:173897 Krutskikh A, et al., Targeted inactivation of the androgen receptor gene in murine proximal epididymis causes epithelial hypotrophy and obstructive azoospermia. Endocrinology. 2011 Feb;152(2):689-96
• All: 7 reference(s)