Clec4e^tm1.1Cfg
Targeted Allele Detail

Summary

• Symbol: Clec4e^tm1.1Cfg
• Name: C-type lectin domain family 4, member e; targeted mutation 1.1, Consortium for Functional Glycomics
• MGI ID: MGI:5052164
• Synonyms: Clec4e^MNA, Clec4e^MNB, Clec4e^tm1.1Psob, Mincle^-
• Gene: Clec4e Location: Chr6:123258748-123266829 bp, - strand Genetic Position: Chr6, 58.35 cM, cytoband F3
• Alliance: Clec4e^tm1.1Cfg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:136334
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 3 and a loxP-flanked PGKneo cassette site was inserted downstream of exon 4. Cre-mediated recombination removed the neo cassette and exons 3 and 4. (J:94077, J:106419, J:136334)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Clec4e Mutation: 24 strains or lines available

References

• Original: J:136334 Wells CA, et al., The macrophage-inducible C-type lectin, mincle, is an essential component of the innate immune response to Candida albicans. J Immunol. 2008 Jun 1;180(11):7404-13
• All: 37 reference(s)