Pdcd10^tm1Kwhi
Targeted Allele Detail

Summary

• Symbol: Pdcd10^tm1Kwhi
• Name: programmed cell death 10; targeted mutation 1, Kevin Whitehead
• MGI ID: MGI:5052183
• Synonyms: Pdcd10^flox
• Gene: Pdcd10 Location: Chr3:75423797-75464159 bp, - strand Genetic Position: Chr3, 33.76 cM, cytoband E3
• Alliance: Pdcd10^tm1Kwhi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173947
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: One loxP site was inserted in intron 3 just 5' to exon 4. A neomycin resistance cassette, a second loxP site and an EGFP construct were inserted 3' to exon 8. Cre mediated excision will remove exons 4-8 and the resistance cassette. This results in a fusion protein composed of exons 1-3 and EGFP. (J:173947)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pdcd10 Mutation: 20 strains or lines available

References

• Original: J:173947 Chan AC, et al., Mutations in 2 distinct genetic pathways result in cerebral cavernous malformations in mice. J Clin Invest. 2011 May 2;121(5):1871-81
• All: 3 reference(s)