Nfib^tm2Rmg
Targeted Allele Detail

Summary

• Symbol: Nfib^tm2Rmg
• Name: nuclear factor I/B; targeted mutation 2, Richard M Gronostajski
• MGI ID: MGI:5052268
• Synonyms: Nfib^flox
• Gene: Nfib Location: Chr4:82208410-82424988 bp, - strand Genetic Position: Chr4, 38.4 cM, cytoband C4-C6
• Alliance: Nfib^tm2Rmg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173651
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Transcript expression detected by RT-PCR is 70-80% of wild-type. (J:173651)

Expression

In Mice Carrying this Mutation:	3 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Nfib Mutation: 91 strains or lines available

References

• Original: J:173651 Hsu YC, et al., Mesenchymal nuclear factor I B regulates cell proliferation and epithelial differentiation during lung maturation. Dev Biol. 2011 Jun 15;354(2):242-52
• All: 9 reference(s)