Ano2^tm1.1Tjj
Targeted Allele Detail

Summary

• Symbol: Ano2^tm1.1Tjj
• Name: anoctamin 2; targeted mutation 1.1, Thomas J Jentsch
• MGI ID: MGI:5052299
• Gene: Ano2 Location: Chr6:125667382-126017089 bp, + strand Genetic Position: Chr6, 59.58 cM
• Alliance: Ano2^tm1.1Tjj page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173937
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A loxP site was inserted upstream of exon 12. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 12. Cre-mediated recombination removed exon 12. The absence of protein expression was confirmed by immunohistochemistry. (J:173937)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ano2 Mutation: 57 strains or lines available

References

• Original: J:173937 Billig GM, et al., Ca(2)-activated Cl currents are dispensable for olfaction. Nat Neurosci. 2011 Jun;14(6):763-9
• All: 8 reference(s)