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Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1, Akiyoshi Uemura
MGI ID: MGI:5052360
Synonyms: R26-Rhoj
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem page
Decreased extraretinal vascular outgrowth in ischemic Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem/Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem Tg(CAG-cre/Esr1*)1Egwa/0 retinas

Show the 5 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:173943
Parent Cell Line:  TT2 (ES Cell)
Strain of Origin:  (C57BL/6NCrlj x CBA/JNCrlj)F1
Mutation
description
Allele Type:    Targeted (Conditional ready, Inserted expressed sequence, Reporter)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem expresses 1 gene
 
Mutation detailsA vector, which contained a floxed neo/stop cassette, the murine cDNA, an FRT-flanked IRES-EGFP cassette, and polyadenylation sequence, was inserted into the locus. (J:173943)
Schematic representation of the targeting strategy for the Gt(ROSA)26Sortm1(CAG-Rhoj,-EGFP)Auem allele
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  992 strains or lines available
References
Original:  J:173943 Fukushima Y, et al., Sema3E-PlexinD1 signaling selectively suppresses disoriented angiogenesis in ischemic retinopathy in mice. J Clin Invest. 2011 May 2;121(5):1974-85
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory