Tg(Myh6-KDM4A)BZpl
Transgene Detail

Summary

• Symbol: Tg(Myh6-KDM4A)BZpl
• Name: transgene insertion B, Zhi-Ping Liu
• MGI ID: MGI:5056132
• Synonyms: Jmjd2a-Tg
• Transgene: Tg(Myh6-KDM4A)BZpl Location: unknown
• Alliance: Tg(Myh6-KDM4A)BZpl page

Tg(Myh6-KDM4A)BZpl/0 mice exhibit cardiac hypertrophy in response to transverse aortic constriction

Show the 1 phenotype image(s) involving this allele.

Transgene origin

• Strain of Origin: FVB

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Myh6-KDM4A)BZpl expresses 1 gene
  Transgene expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  KDM4A (9682)

  Kdm4a

  (MGI:2446210)

• Mutation details: The mouse promoter drives cardiomyocyte-specific expression of the human cDNA. Two lines were generated with a 2-fold and 8-fold increase in expression in lines A and B, respectively. (J:173908)

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:173908 Zhang QJ, et al., The histone trimethyllysine demethylase JMJD2A promotes cardiac hypertrophy in response to hypertrophic stimuli in mice. J Clin Invest. 2011 Jun 1;121(6):2447-56
• All: 1 reference(s)