Cd1d1^tm1.1Aben
Targeted Allele Detail

Summary

• Symbol: Cd1d1^tm1.1Aben
• Name: CD1d1 antigen; targeted mutation 1.1, Albert Bendelac
• MGI ID: MGI:5056283
• Synonyms: CD1.1 Conditional, Cd1d1/Cd1d2^tm1.1Aben, cd1d1^fl, CD1d^fl
• Gene: Cd1d1 Location: Chr3:86903141-86906748 bp, - strand Genetic Position: Chr3, 37.91 cM
• Alliance: Cd1d1^tm1.1Aben page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174336
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Exons 2-6 were flanked by loxP sites. Flp-mediated recombination removed the neo cassette. (J:174336)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cd1d1 Mutation: 35 strains or lines available

Notes

Because the C57BL/6 ES cells used to generate the allele contain a natural frameshift mutation in Cd1d2 that prevents its surface expression, deletion of Cd1d1 is sufficient to abolish all CD1D protein from the cell surface.

References

• Original: J:174336 Bendelac A, Direct Data Submission 2011/08/08. MGI Direct Data Submission. 2011
• All: 11 reference(s)