Tubb2b^brdp
Chemically induced Allele Detail

Summary

• Symbol: Tubb2b^brdp
• Name: tubulin, beta 2B class IIB; brain dimple
• MGI ID: MGI:5056364
• Gene: Tubb2b Location: Chr13:34310991-34314337 bp, - strand Genetic Position: Chr13, 14.04 cM, cytoband A4
• Alliance: Tubb2b^brdp page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: This ENU-induced mutation was isolated in a screen at the University of Pittsburgh. The molecular lesion is an A to G substitution at coding nucleotide 740 in exon 4 of the cDNA (c.740A>G, NM_023716). This changes the asparagine residue to serine at position 247 of the encoded protein (N247S). (J:201099)

Disease models

Expression

In Structures Affected by this Mutation:

16 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tubb2b Mutation: 21 strains or lines available

References

• Original: J:174027 Stottmann RW, et al., Focusing Forward Genetics: A Tripartite ENU Screen for Neurodevelopmental Mutations in the Mouse. Genetics. 2011 Jul;188(3):615-24
• All: 3 reference(s)