Casp3^hith2
Chemically induced Allele Detail

Summary

• Symbol: Casp3^hith2
• Name: caspase 3; hole in the head 2
• MGI ID: MGI:5056374
• Gene: Casp3 Location: Chr8:47070326-47092724 bp, + strand Genetic Position: Chr8, 26.39 cM
• Alliance: Casp3^hith2 page

Mutation origin

• Strain of Origin: A/J

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Nucleotide substitutions
• Mutation details: Identified in an ENU screen and mapped to a 4 Mb interval on Chromosome 8 containing Casp3. A mutation two bases upstream of exon 3 results in splicing errors causing exon 3 splicing to be 4 nucleotides into the wild type exon or loss of exon 3 altogether. Both forms result in premature stop codons. (J:174027)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Casp3 Mutation: 33 strains or lines available

References

• Original: J:174027 Stottmann RW, et al., Focusing Forward Genetics: A Tripartite ENU Screen for Neurodevelopmental Mutations in the Mouse. Genetics. 2011 Jul;188(3):615-24
• All: 1 reference(s)