Padi4^tm1.1Ywan
Targeted Allele Detail

Summary

• Symbol: Padi4^tm1.1Ywan
• Name: peptidyl arginine deiminase, type IV; targeted mutation 1.1, Yanming Wang
• MGI ID: MGI:5056532
• Synonyms: PAD4^-
• Gene: Padi4 Location: Chr4:140473176-140501547 bp, - strand Genetic Position: Chr4, 72.34 cM, cytoband E1
• Alliance: Padi4^tm1.1Ywan page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:165718
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: Molecular Notes: Exon 2 of the gene was replaced with the FRT site-flanked neomycin cassette. Exon 2 deletion generates a frame shift causing premature termination of the protein. The neomycin cassette was removed by crossing with filppase-expressing mice. No protein product was detected by western blot in peripheral blood neutrophils from homozygous mouse. (J:165718)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Padi4 Mutation: 41 strains or lines available

References

• Original: J:165718 Li P, et al., PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps. J Exp Med. 2010 Aug 30;207(9):1853-62
• All: 19 reference(s)