Smad2^tm1.1Nomu
Targeted Allele Detail

Summary

• Symbol: Smad2^tm1.1Nomu
• Name: SMAD family member 2; targeted mutation 1.1, Masatoshi Nomura
• MGI ID: MGI:5085284
• Synonyms: Smad2^flox
• Gene: Smad2 Location: Chr18:76374651-76444034 bp, + strand Genetic Position: Chr18, 51.42 cM
• Alliance: Smad2^tm1.1Nomu page

Cerebellar ataxia in Smad2^tm1.1Nomu/Smad2^tm1.1Nomu Tg(Nes-cre)1Kln/0 mice

Show the 6 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173787
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 7. A floxed neo cassette was inserted downstream of exon 8. Cre-mediated recombination removed the neo cassette and left exons 7 and 8 floxed. (J:173787)

Generation of the floxed Smad2^tm1.1Nomu allele

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Smad2 Mutation: 52 strains or lines available

References

• Original: J:173787 Wang L, et al., Smad2 protein disruption in the central nervous system leads to aberrant cerebellar development and early postnatal ataxia in mice. J Biol Chem. 2011 May 27;286(21):18766-74
• All: 9 reference(s)