Ccm2^tm2.1Sbn
Targeted Allele Detail

Summary

• Symbol: Ccm2^tm2.1Sbn
• Name: cerebral cavernous malformation 2; targeted mutation 2.1, Ulrich Siebenlist
• MGI ID: MGI:5085315
• Synonyms: Ccm2^flox
• Gene: Ccm2 Location: Chr11:6496887-6546744 bp, + strand Genetic Position: Chr11, 4.45 cM
• Alliance: Ccm2^tm2.1Sbn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174085
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 3 and an FRT flanked neo cassette and second loxP site were inserted downstream of exon 4 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:174085)

Disease models

Expression

In Structures Affected by this Mutation:

6 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccm2 Mutation: 48 strains or lines available

References

• Original: J:174085 Cunningham K, et al., Conditional deletion of Ccm2 causes hemorrhage in the adult brain: a mouse model of human cerebral cavernous malformations. Hum Mol Genet. 2011 Aug 15;20(16):3198-206
• All: 1 reference(s)