Nlrp6^tm1Flv
Targeted Allele Detail

Summary

• Symbol: Nlrp6^tm1Flv
• Name: NLR family, pyrin domain containing 6; targeted mutation 1, Richard A Flavell
• MGI ID: MGI:5085850
• Gene: Nlrp6 Location: Chr7:140500815-140509105 bp, + strand Genetic Position: Chr7, 86.14 cM, cytoband F4
• Alliance: Nlrp6^tm1Flv page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173245
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129 and C57BL/6

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Exons 1 and 2 were replaced with an IRES/nuclear localized lacZ and neo cassette. (J:173245)

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp6 Mutation: 45 strains or lines available

References

• Original: J:173245 Elinav E, et al., NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis. Cell. 2011 May 27;145(5):745-57
• All: 35 reference(s)