Stra6^{Gt(OST353837)Lex}
Gene trapped Allele Detail

Summary

• Symbol: Stra6^{Gt(OST353837)Lex}
• Name: stimulated by retinoic acid gene 6; gene trap OST353837, Lexicon Genetics
• MGI ID: MGI:5085884
• Gene: Stra6 Location: Chr9:57971071-58061279 bp, + strand Genetic Position: Chr9, 31.63 cM, cytoband C
• Alliance: Stra6^{Gt(OST353837)Lex} page

Mutation origin

• Mutant Cell Line: OST353837
• Germline Transmission: Earliest citation of germline transmission: J:161922
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S5/SvEvBrd
• Project Collection: Lexicon

Mutation description

• Allele Type: Gene trapped (Null/knockout, Reporter)
• Mutation: Insertion of gene trap vector
• Mutation details: The Stra6 gene consists of 19 exons. Retroviral insertion disrupted the gene in the intron between coding exons 1 and 2 (NCBI accession NM_009291.1). RT-PCR analysis revealed that the transcript was absent in the homozygous mutant mice. (J:161922)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Stra6 Mutation: 50 strains or lines available

Notes

This Lexicon Genetics gene trap mutation was generated in either Lex-1 or Lex-2 (129S5/SvEvBrd) parental ES cell line. The specific ES cell line in which this mutation was made is not specified.

References

• Original: J:161922 Tang T, et al., A mouse knockout library for secreted and transmembrane proteins. Nat Biotechnol. 2010 Jul;28(7):749-55
• All: 3 reference(s)