Lrrtm1^tm1.1Jaru
Targeted Allele Detail

Summary

• Symbol: Lrrtm1^tm1.1Jaru
• Name: leucine rich repeat transmembrane neuronal 1; targeted mutation 1.1, Jun Aruga
• MGI ID: MGI:5085889
• Gene: Lrrtm1 Location: Chr6:77219672-77234774 bp, + strand Genetic Position: Chr6, 33.89 cM
• Alliance: Lrrtm1^tm1.1Jaru page

Approach toward inanimate objects is altered in Lrrtm1^tm1.1Jaru/Lrrtm1^tm1.1Jaru mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174350
• Parent Cell Line: CMTI-2 (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: A loxP site was inserted into exon 2 upstream of the translation initiation site. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the coding region and neo cassette. (J:174350)

Generation of the Lrrtm1^tm1.1Jaru allele

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Lrrtm1 Mutation: 37 strains or lines available

References

• Original: J:174350 Takashima N, et al., Impaired cognitive function and altered hippocampal synapse morphology in mice lacking lrrtm1, a gene associated with schizophrenia. PLoS One. 2011;6(7):e22716
• All: 1 reference(s)