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Gt(ROSA)26Sortm2Bet
Targeted Allele Detail
Summary
Symbol: Gt(ROSA)26Sortm2Bet
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 2, Bernhard Bettler
MGI ID: MGI:5085997
Synonyms: N2ICD
Gene: Gt(ROSA)26Sor  Location: Chr6:113044389-113054205 bp, - strand  Genetic Position: Chr6, 52.73 cM
Alliance: Gt(ROSA)26Sortm2Bet page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:174261
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  BALB/c
Mutation
description
Allele Type:    Targeted
Mutation:    Insertion
 
Mutation detailsRBCE was used to insert an FRT flanked CAG followed by a floxed transcriptional stop site, a 5xMyc tagged Notch2 intracellular domain cDNA and a neomycin selection cassette into the targeting site of Gt(ROSA)26Sor ES cells. (J:174261)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  992 strains or lines available
References
Original:  J:174261 Tchorz JS, et al., Notch2 signaling promotes biliary epithelial cell fate specification and tubulogenesis during bile duct development in mice. Hepatology. 2009 Sep;50(3):871-9
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory