Amer1^tm1.1Nbar
Targeted Allele Detail

Summary

• Symbol: Amer1^tm1.1Nbar
• Name: APC membrane recruitment 1; targeted mutation 1.1, Nabeel Bardeesy
• MGI ID: MGI:5086003
• Synonyms: Wtx^lox
• Gene: Amer1 Location: ChrX:94463919-94488446 bp, - strand Genetic Position: ChrX, 41.99 cM
• Alliance: Amer1^tm1.1Nbar page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173242
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an FRT flanked neo cassette and second loxP site were inserted in the untranslated region of exon 2 via homologous recombination. Flp mediated recombination removed the neo cassette. (J:173242)

Disease models

Expression

In Structures Affected by this Mutation:

7 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Amer1 Mutation: 2 strains or lines available

References

• Original: J:173242 Moisan A, et al., The WTX tumor suppressor regulates mesenchymal progenitor cell fate specification. Dev Cell. 2011 May 17;20(5):583-96
• All: 1 reference(s)