Mir140^tm1.1Tkob
Targeted Allele Detail

Summary

• Symbol: Mir140^tm1.1Tkob
• Name: microRNA 140; targeted mutation 1.1, Tatsuya Kobayashi
• MGI ID: MGI:5086252
• Gene: Mir140 Location: Chr8:108277876-108277945 bp, + strand Genetic Position: Chr8, 54.33 cM
• Alliance: Mir140^tm1.1Tkob page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174096
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The sequence corresponding to the microRNA was replaced with an FRT-flanked neo cassette. Flp-mediated recombination removed the neo cassette. (J:174096)

Expression

In Structures Affected by this Mutation:

8 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Mir140 Mutation: 3 strains or lines available

References

• Original: J:174096 Nakamura Y, et al., Chondrocyte-Specific MicroRNA-140 Regulates Endochondral Bone Development and Targets Dnpep To Modulate Bone Morphogenetic Protein Signaling. Mol Cell Biol. 2011 Jul;31(14):3019-28
• All: 4 reference(s)