Cxadr^tm1.1Ics
Targeted Allele Detail

Summary

• Symbol: Cxadr^tm1.1Ics
• Name: coxsackie virus and adenovirus receptor; targeted mutation 1.1, Mouse Clinical Institute
• MGI ID: MGI:5086256
• Gene: Cxadr Location: Chr16:78098377-78156662 bp, + strand Genetic Position: Chr16, 45.28 cM, cytoband C
• Alliance: Cxadr^tm1.1Ics page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174138
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 was flanked with loxP sites and an FRT flanked neo cassette was inserted via homologous recombination. Flp mediated recombination removed the neo cassette. RT-PCR, western blot and indirect immunofluorescence confirmed normal mRNA and protein expression and localization in homozygous mice. (J:174138)

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Cxadr Mutation: 15 strains or lines available

References

• Original: J:174138 Pazirandeh A, et al., Multiple Phenotypes in Adult Mice following Inactivation of the Coxsackievirus and Adenovirus Receptor (Car) Gene. PLoS One. 2011;6(6):e20203
• All: 3 reference(s)