Prkcd^tm1.1Khn
Targeted Allele Detail

Summary

• Symbol: Prkcd^tm1.1Khn
• Name: protein kinase C, delta; targeted mutation 1.1, Ronald Kahn
• MGI ID: MGI:5086282
• Synonyms: Prkcd loxP
• Gene: Prkcd Location: Chr14:30317311-30348167 bp, - strand Genetic Position: Chr14, 18.82 cM
• Alliance: Prkcd^tm1.1Khn page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173902
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A floxed neo cassette was inserted upstream of exon 2. A loxP site was inserted downstream of exon 2. Cre-mediated recombination removed the neo cassette and left exon 2 floxed. (J:173902)

Generation of the Prkcd^tm1.1Khn allele

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Prkcd Mutation: 54 strains or lines available

References

• Original: J:173902 Bezy O, et al., PKCdelta regulates hepatic insulin sensitivity and hepatosteatosis in mice and humans. J Clin Invest. 2011 Jun 1;121(6):2504-17
• All: 3 reference(s)