Pex5l^tm1.1Chet
Targeted Allele Detail

Summary

• Symbol: Pex5l^tm1.1Chet
• Name: peroxisomal biogenesis factor 5-like; targeted mutation 1.1, Dane Chetkovich
• MGI ID: MGI:5139912
• Synonyms: TRIP8b^-
• Gene: Pex5l Location: Chr3:33003557-33197396 bp, - strand Genetic Position: Chr3, 15.94 cM, cytoband B
• Alliance: Pex5l^tm1.1Chet page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173355
• Parent Cell Line: PRX-B6N (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Cre-mediated recombination removed exons 6 and 7 and the neo cassette. The absence of isoform b expression was confirmed by western blot analysis on brain extracts. (J:173355)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Pex5l Mutation: 41 strains or lines available

References

• Original: J:173355 Lewis AS, et al., Deletion of the hyperpolarization-activated cyclic nucleotide-gated channel auxiliary subunit TRIP8b impairs hippocampal Ih localization and function and promotes antidepressant behavior in mice. J Neurosci. 2011 May 18;31(20):7424-40
• All: 9 reference(s)