Serpinb9^tm1.1Pib
Targeted Allele Detail

Summary

• Symbol: Serpinb9^tm1.1Pib
• Name: serine (or cysteine) peptidase inhibitor, clade B, member 9; targeted mutation 1.1, Phillip I Bird
• MGI ID: MGI:5140012
• Gene: Serpinb9 Location: Chr13:33187233-33201940 bp, + strand Genetic Position: Chr13, 13.79 cM
• Alliance: Serpinb9^tm1.1Pib page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:252016
• Parent Cell Line: Bruce 4 (ES Cell)
• Strain of Origin: B6.Cg-Thy1^a

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An EGFP reporter gene was inserted at the ATG translation start site in exon 2 in frame with the coding sequence replacing some of the endogenous sequence. Cre-mediated recombination removed the floxed neomycin resistance cassette inserted downstream of the reporter gene. Western blot analysis confirmed the absence of protein expression in the spleen cell lysate. (J:252016, J:252153)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Serpinb9 Mutation: 34 strains or lines available

References

• Original: J:252016 Rizzitelli A, et al., Serpinb9 (Spi6)-deficient mice are impaired in dendritic cell-mediated antigen cross-presentation. Immunol Cell Biol. 2012 Oct;90(9):841-51
• All: 4 reference(s)