Pou2f3^tm1Abek
Targeted Allele Detail

Summary

• Symbol: Pou2f3^tm1Abek
• Name: POU domain, class 2, transcription factor 3; targeted mutation 1, Keiko Abe
• MGI ID: MGI:5140071
• Synonyms: Skn-1a^-
• Gene: Pou2f3 Location: Chr9:43035222-43117052 bp, - strand Genetic Position: Chr9, 24.21 cM
• Alliance: Pou2f3^tm1Abek page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173905
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: An approximately 4 kb fragment, including exons 7 - 9 encoding for the POU homeodomain and a part of the POU?specific domain, was replaced with a tk-neo cassette via homologous recombination. In situ and immunohistochemical analysis indicated the expression of a truncated mRNA in a small population of basal cells and the absence of the a isoform of the protein in the taste buds of homozygous mice. (J:173905)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Pou2f3 Mutation: 34 strains or lines available

References

• Original: J:173905 Matsumoto I, et al., Skn-1a (Pou2f3) specifies taste receptor cell lineage. Nat Neurosci. 2011 Jun;14(6):685-7
• All: 23 reference(s)