Angpt1^tm1.1Seq
Targeted Allele Detail

Summary

• Symbol: Angpt1^tm1.1Seq
• Name: angiopoietin 1; targeted mutation 1.1, Susan E Quaggin
• MGI ID: MGI:5140300
• Synonyms: Angpt1^lox
• Gene: Angpt1 Location: Chr15:42288119-42540373 bp, - strand Genetic Position: Chr15, 16.69 cM
• Alliance: Angpt1^tm1.1Seq page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174022
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 1. An FRT-flanked neo cassette with a 3' loxP site was inserted downstream of exon 1. Flp-mediated recombination removed the neo cassette. (J:174022)

Generation of the Angpt1^tm1.1Seq allele

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angpt1 Mutation: 35 strains or lines available

References

• Original: J:174022 Jeansson M, et al., Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest. 2011 Jun 1;121(6):2278-89
• All: 11 reference(s)