Angpt1^tm1.2Seq
Targeted Allele Detail

Summary

• Symbol: Angpt1^tm1.2Seq
• Name: angiopoietin 1; targeted mutation 1.2, Susan E Quaggin
• MGI ID: MGI:5140301
• Synonyms: Angpt1^del
• Gene: Angpt1 Location: Chr15:42288119-42540373 bp, - strand Genetic Position: Chr15, 16.69 cM
• Alliance: Angpt1^tm1.2Seq page

Loss of trabeculations in the heart of E9.5 and E10.5 Angpt1^tm1.2Seq/Angpt1^tm1.2Seq Kdr^tm2.1Jrt/Kdr⁺ embryos

Show the 3 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174022
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Cre-mediated recombination removed exon 1 from Angpt^tm1.1Seq. (J:174022)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Angpt1 Mutation: 35 strains or lines available

References

• Original: J:174022 Jeansson M, et al., Angiopoietin-1 is essential in mouse vasculature during development and in response to injury. J Clin Invest. 2011 Jun 1;121(6):2278-89
• All: 4 reference(s)