Nlrp6^tm1Macha
Targeted Allele Detail

Summary

• Symbol: Nlrp6^tm1Macha
• Name: NLR family, pyrin domain containing 6; targeted mutation 1, Mathias Chamaillard
• MGI ID: MGI:5140329
• Gene: Nlrp6 Location: Chr7:140500815-140509105 bp, + strand Genetic Position: Chr7, 86.14 cM, cytoband F4
• Alliance: Nlrp6^tm1Macha page

Increased susceptibility to induced colitis in Nlrp6^tm1Macha/Nlrp6^tm1Macha mice

Show the 2 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173352
• Parent Cell Line: Lex-1 (ES Cell)
• Strain of Origin: 129S5/SvEvBrd

Mutation description

Allele Type: Targeted (Null/knockout) Mutations: Insertion, Intragenic deletion Mutation details: The first two exons were replaced with a neo cassette. The absence of transcript expression was confirmed by RT-PCR. (J:173352)

Generation of the Nlrp6^tm1Macha allele

Expression

In Structures Affected by this Mutation:

5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nlrp6 Mutation: 45 strains or lines available

References

• Original: J:173352 Normand S, et al., Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injury. Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9601-6
• All: 2 reference(s)