Tex19.1^{tm1(rtTA2S*M2,lacZ)Jw}
Targeted Allele Detail

Summary

• Symbol: Tex19.1^{tm1(rtTA2S*M2,lacZ)Jw}
• Name: testis expressed gene 19.1; targeted mutation 1, Jeremy Wang
• MGI ID: MGI:5140347
• Synonyms: Tex19.1^-
• Gene: Tex19.1 Location: Chr11:121036969-121039140 bp, + strand Genetic Position: Chr11, 85.0 cM
• Alliance: Tex19.1^{tm1(rtTA2S*M2,lacZ)Jw} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:166982
• Parent Cell Line: v6.5 (ES Cell)
• Strain of Origin: (C57BL/6 x 129S4/SvJae)F1

Mutation description

• Allele Type: Targeted
• Mutations: Insertion, Intragenic deletion
• Mutation details: The open reading frame, contained entirely in exon 3, was replaced by a cassette composed of rtTA2S*M2, an IRES and a lacZ-SV40 polyadenylataion signal, followed by a floxed PGK-new selection gene. Western blot analysis confirmed the absence of protein in the testes. (J:166982)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tex19.1 Mutation: 10 strains or lines available

References

• Original: J:166982 Yang F, et al., The ubiquitin ligase Ubr2, a recognition E3 component of the N-end rule pathway, stabilizes Tex19.1 during spermatogenesis. PLoS One. 2010;5(11):e14017
• All: 1 reference(s)