Rpl27a^Sfa
Chemically induced Allele Detail

Summary

• Symbol: Rpl27a^Sfa
• Name: ribosomal protein L27A; sooty foot ataxia
• MGI ID: MGI:5140351
• Synonyms: SFA
• Gene: Rpl27a Location: Chr7:109118354-109121574 bp, + strand Genetic Position: Chr7, 57.26 cM, cytoband E2-F1
• Alliance: Rpl27a^Sfa page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: Mutagenesis for Dev. Defects

Mutation description

• Allele Type: Chemically induced (ENU)
• Mutation: Single point mutation
• Mutation details: An A to G point mutation is located at position -15 in the 3' splice acceptor of intron 4 (IVS4-15A > G). Quantitative-PCR indicates lower expression levels in heterozygous mice. (J:85113, J:174216)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying Rpl27a^Sfa

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Rpl27a Mutation: 52 strains or lines available

References

• Original: J:174216 Terzian T, et al., Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug;224(4):540-52
• All: 2 reference(s)