Igh^tm1.1Twin
Targeted Allele Detail

Summary

• Symbol: Igh^tm1.1Twin
• Name: immunoglobulin heavy chain complex; targeted mutation 1.1, Thomas H Winkler
• MGI ID: MGI:5140396
• Synonyms: IgH^Emu-GFP
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:174233
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutation: Insertion
• Mutation details: A GFP gene and neo cassette was inserted downstream of the Emu region. Cre-mediated recombination removed the neo cassette. (J:174233)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 44 strains or lines available

References

• Original: J:174233 Brenner S, et al., A hypomorphic IgH-chain allele affects development of B-cell subsets and favours receptor editing. EMBO J. 2011;30(13):2705-18
• All: 1 reference(s)