Gabra2^tm2.1Uru
Targeted Allele Detail

Summary

• Symbol: Gabra2^tm2.1Uru
• Name: gamma-aminobutyric acid type A receptor subunit alpha 2; targeted mutation 2.1, Uwe Rudolph
• MGI ID: MGI:5140553
• Synonyms: alpha2^fl
• Gene: Gabra2 Location: Chr5:71115735-71253192 bp, - strand Genetic Position: Chr5, 37.59 cM
• Alliance: Gabra2^tm2.1Uru page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173378
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 5. An FRT-flanked neo cassette with a 5' loxP site was inserted downstream of exon 5. Flp-mediated recombination removed the neo cassette and left exon 5 floxed. (J:173378)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Gabra2 Mutation: 36 strains or lines available

References

• Original: J:173378 Witschi R, et al., Presynaptic {alpha}2-GABAA Receptors in Primary Afferent Depolarization and Spinal Pain Control. J Neurosci. 2011 Jun 1;31(22):8134-8142
• All: 13 reference(s)