Ccdc88a^tm3.1Mat
Targeted Allele Detail

Summary

• Symbol: Ccdc88a^tm3.1Mat
• Name: coiled coil domain containing 88A; targeted mutation 3.1, Masahide Takahashi
• MGI ID: MGI:5140605
• Synonyms: Girdin Basic-mut
• Gene: Ccdc88a Location: Chr11:29323658-29460808 bp, + strand Genetic Position: Chr11, 16.61 cM
• Alliance: Ccdc88a^tm3.1Mat page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:173379
• Parent Cell Line: CSL3 (ES Cell)
• Strain of Origin: 129S6/SvEvTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details: Exon 24 was replaced with a modified exon 24 in which nucleotide substitution results in the amino acid substitutions of 6 amino acids in the basic amino acid residue-rich region (KMRKLIKSKK to AMAALIASAA). A floxed neo cassette inserted downstream of the modified exon 24 was removed by cre-mediated recombination. (J:173379)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ccdc88a Mutation: 76 strains or lines available

References

• Original: J:173379 Wang Y, et al., Girdin Is an Intrinsic Regulator of Neuroblast Chain Migration in the Rostral Migratory Stream of the Postnatal Brain. J Neurosci. 2011 Jun 1;31(22):8109-8122
• All: 2 reference(s)